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Drug discovery in the next decade: innovation needed ASAPBENNANI, Youssef L.Drug discovery today. 2011, Vol 16, Num 17-18, pp 779-792, issn 1359-6446, 14 p.Article

A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitorsTIANSHENG WANG; LEDEBOER, Mark W; DUFFY, John P et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 1, pp 153-156, issn 0960-894X, 4 p.Article

Discovery of S-phase arresting agents derived from noscapineANDERSON, James T; TING, Anthony E; RUNDLETT, Stephen E et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 8, pp 2756-2758, issn 0022-2623, 3 p.Article

A new class of potent non-imidazole H3 antagonists: 2-aminoethylbenzofuransCOWART, Marion; PRATT, John K; STEWART, Andrew O et al.Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 3, pp 689-693, issn 0960-894X, 5 p.Article

Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: Novel and selective histamine H3 receptor antagonistsFAGHIH, Ramin; DWIGHT, Wesley; JIA BAO PAN et al.Bioorganic & medicinal chemistry letters (Print). 2003, Vol 13, Num 7, pp 1325-1328, issn 0960-894X, 4 p.Article

Aminoalkoxybiphenylnitriles as histamine-3 receptor ligandsFAGHIH, Ramin; DWIGHT, Wesley; VASUDEVAN, Anil et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 21, pp 3077-3079, issn 0960-894X, 3 p.Article

In Vitro and In Vivo Isotope Effects with Hepatitis C Protease Inhibitors: Enhanced Plasma Exposure of Deuterated Telaprevir versus Telaprevir in RatsMALTAIS, François; YOUNG CHUN JUNG; TSAO, Hong et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 24, pp 7993-8001, issn 0022-2623, 9 p.Article

Identification of novel and improved antimitotic agents derived from noscapineANDERSON, James T; TING, Anthony E; MURPHY, Steven M et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 23, pp 7096-7098, issn 0022-2623, 3 p.Article

An efficient multigram synthesis of the potent histamine H3 antagonist GT-2331 and the reassessment of the absolute configurationHUAQING LIU; KERDESKY, Francis A; BLACK, Lawrence A et al.Journal of organic chemistry. 2004, Vol 69, Num 1, pp 192-194, issn 0022-3263, 3 p.Article

The identification and optimization of 2,4-diketobutyric acids as flap endonuclease 1 inhibitorsNATHAN TUMEY, L; HUCK, Bayard; BAILEY, Andrew et al.Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 19, pp 4915-4918, issn 0960-894X, 4 p.Article

Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TORCRUZ, M. Cristina; GOLDSTEIN, Alan L; BLANKENSHIP, Jill et al.Antimicrobial agents and chemotherapy. 2001, Vol 45, Num 11, pp 3162-3170, issn 0066-4804Article

Structure-activity relationships of arylbenzofuran H3 receptor antagonistsGFESSER, Gregory A; FAGHIH, Ramin; BENNANI, Youssef L et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 10, pp 2559-2563, issn 0960-894X, 5 p.Article

Investigation of 4-piperidinols as novel H3 antagonistsANDERSON, James T; CAMPBELL, Michael; JIANMIN WANG et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 21, pp 6246-6249, issn 0960-894X, 4 p.Article

Design of a New Histamine H3 Receptor Antagonist Chemotype: (3aR,6aR)-5-Alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, Synthesis, and Structure—Activity RelationshipsCHEN ZHAO; MINGHUA SUN; COWART, Marlon D et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 15, pp 4640-4649, issn 0022-2623, 10 p.Article

The Alkaloid Conessine and Analogues as Potent Histamine H3 Receptor AntagonistsCHEN ZHAO; MINGHUA SUN; MARSH, Kennan C et al.Journal of medicinal chemistry (Print). 2008, Vol 51, Num 17, pp 5423-5430, issn 0022-2623, 8 p.Article

The identification of pyrimidine-diazabicyclo[3.3.0]octane derivatives as 5-HT2C receptor agonistsHUCK, Bayard R; LLAMAS, Luis; BENNANI, Youssef L et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 11, pp 2891-2894, issn 0960-894X, 4 p.Article

4-2-[2-(2(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-ylbenzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attentionCOWART, Marlon; FAGHIH, Ramin; FOX, Gerard B et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 1, pp 38-55, issn 0022-2623, 18 p.Article

Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonistESBENSHADE, Timothy A; FOX, Gerard B; FAGHIH, Ramin et al.Biochemical pharmacology. 2004, Vol 68, Num 5, pp 933-945, issn 0006-2952, 13 p.Article

Effects of histamine H3 receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pupFOX, Gerard B; JIA BAO PAN; ESBENSHADE, Timothy A et al.Behavioural brain research. 2002, Vol 131, Num 1-2, pp 151-161, issn 0166-4328Article

Structure-activity relationships of non-imidazole H3 receptor ligands. Part 1FAGHIH, Ramin; DWIGHT, Wesley; HANCOCK, Arthur A et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 15, pp 2031-2034, issn 0960-894XArticle

2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2LEDEBOER, Mark W; PIERCE, Albert C; SHLYAKTER, Dina et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 23, pp 6529-6533, issn 0960-894X, 5 p.Article

Janus Kinase 2 Inhibitors. Synthesis and Characterization of a Novel Polycyclic AzaindoleTIANSHENG WANG; DUFFY, John P; SHLYAKTER, Dina et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 24, pp 7938-7941, issn 0022-2623, 4 p.Article

4 -[6 -(2 -Aminoethyl )naphthalen -2 -yl ]benzonitriles are potent histamine H3 receptor antagonists with high CNS penetrationBLACK, Lawrence A; NERSESIAN, Diana L; SHARMA, Padam et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 5, pp 1443-1446, issn 0960-894X, 4 p.Article

Isosteric ramatroban analogs : selective and potent CRTH-2 antagonistsROBARGE, Michael J; BOM, David C; HANNIFORD, Doug et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 6, pp 1749-1753, issn 0960-894X, 5 p.Article

The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitorsTUMEY, L. Nathan; BOM, David; MURPHY, Steven et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 2, pp 277-281, issn 0960-894X, 5 p.Article

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